Isolation and spectroscopy study of the psoralens from Ficus Sycomorus sap. Its thermal and kinetic effects in collagen forms

Christos Petrou, Stelios Mavromoustakos, Constantinos Potamitis, Petros Chatzigeorgiou, George Efthimiou, et al

Abstract


Psoralen and antioxidants were isolated for the first time from Ficus Sycomorus (FS) sap, localised in the trunk of the tree and are characterized by 1D and 2D NMR spectroscopy. The bioactive constituents of the sap were incorporated in the collagen gel, which is prepared further in membranes and matrices forms, using a methodology developed in our laboratories. Collagen gels with FS content were dried by different processes like freeze-drying and free drying at 25 oC in order to obtain matrices and membranes because they will be used as vehicles for topical systems with controlled release of bioactive components from FS. The thermal and structural changes caused by the presence of psoralens in membranes and matrices have been studied using Differential Scanning Calorimetry, UV and IR. In addition, in vitro kinetic studies revealed the possible mechanisms of the FS release and showed that FS extract has the potential to be used in these forms as a future therapeutic approach for psoriasis.

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International Journal of Basic Medical Sciences and Pharmacy (IJBMSP): ISSN: 2049-4963