Effect of Aluminium Acetyl Acetonate on the Chemical Status of Glutathione by Influential Parameters in Aqueous Medium

Haroon Khan, Mohammad Farid Khan, Naseem Ullah, Muhammad Mukhtiar, Nahee Barkat Ali, Abdul wahab3, Arshad Farid, et al

Abstract


Aluminium is the most abundant metal and the third most abundant element, after oxygen and silicon, in the earth's
crust. It is widely distributed and constitutes approximately 8 percent of the earth's surface layer. However, Aluminium is a
very reactive element and is never found as the free metal in nature. Ellman’s method was used to check the concentration,
pH, and temperature and time dependent effect of Aluminium- acetyle acetonate on GSH status in aqueous medium.
Aluminium- acetyle acetonate reduced the GSH level with concentration, pH, temperature and time. GSH reduction is due to
oxidation of reduced GSH by Aluminium- acetyl acetonate by changing it to GSSG or by forming GS-Aluminium conjugate.
Present study is in vitro condition which may present the model for in vivo condition.

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International Journal of Basic Medical Sciences and Pharmacy (IJBMSP): ISSN: 2049-4963