Evaluation of Hypoglycemic activity of Thymus serpyllum Linn in glucose treated mice

Alamgeer, Muhammad Naveed Mushtaq, Muhammad Rashid, Muhammad Nasir Hayat Malik, Taseer Ahmad1, Abdul Qayyum Khan, Ibrahim Javed and Haseeb

Abstract


Thymus serpyllum Linn. was evaluated for its hypoglycemic activity in 10 % d-glucose treated mice. The blood glucose level of glucose-fed mice treated with aqueous extract of Thymus serpyllum Linn. for one month remained within the normal range while the blood glucose level of glucose-fed untreated mice was significantly (P<0.001) increased as compared to control. The aqueous extract also exhibited a significant (P<0.05) increase in the weight of pancreas, heart and kidneys of the d-glucose-treated mice. The intraperitoneal (i.p) median lethal dose (LD50) of the aqueous extract of Thymus serpyllum was found to be 1050 mg/kg in mice. The result obtained from this study showed that the aqueous extract of Thymus serpyllum possesses hypoglycemic activity and supports the ethno medical claim of the use of the plant in treatment of hyperglycemic states.

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International Journal of Basic Medical Sciences and Pharmacy (IJBMSP): ISSN: 2049-4963