Renal Adverse Effect in Sold Cancer Patients Treated With Cytotoxic Agents

Talha Bin Fayyaz, Noorulain, Nusrat Bano, Mirza Tasawer Baig Durnaz Baloch, Aisha Jabeen, Quratul Ain Leghari, Shazia Adnan and Sikandar khan sherwani

Abstract


Severe or pertinent nephrotoxicity interferes with cytotoxic chemotherapy resulting in dose reductions, treatment delays or cessation of therapy. Chemotherapy induced nephrotoxicity is associated with anaphylactic reactions, vascular complications, decreased renal perfusion and is relative to the cumulative dose intensity. Risk of nephrotoxicity is higher in the elderly and diabetic patients. Patients with previous nephro diseases such as nephritis and comorbidities i.e. anemia, malnutrition and renal damages are prone to an added risk of nephrotoxicity. This review consolidates the pattern of nephro adverse effects associated with each component of the cytotoxic agents regimen e.g. cisplatin, ifosfamide, carboplatin etc. Higher propensities of nephro adverse effects are associated with the cytotoxic agents, intensified by the incorporation of more than one drug at a time. In conclusion the nephro biomarkers like urinary kidney injury molecule- 1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), blood urea nitrogen, serum creatinine etc should be monitored in the patient under a cytotoxic treatment plan as well as purposefully assessed during follow-up visits of the patients.

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International Journal of Basic Medical Sciences and Pharmacy (IJBMSP): ISSN: 2049-4963