In-Vivo and In-Vitro Anti-Inflammatory Activity of Aquilaria agallocha Oil

Habibur Rahman, Kamala Vakati, M Chinna Eswaraiah

Abstract


The present study aimed for evaluation of Aquilaria agallocha oil obtained by hydro-distillation from the woods for in-vivo and in-vitro anti-inflammatory activity. The oil was screened for in-vivo anti-inflammatory activity by carrageenan-induced paw edema in rat model and In-vitro anti-inflammatory activity by human red blood cell membrane stabilization method. The potency of the oil was compared with standard Diclofenac (10 mg/kg). The oil showed significant reduction of edema in carrageenan induced rat paw edema model maximum at 3 hr for AAO 50 mg/kg, AAO 100 mg/kg and diclofenec 10 mg/kg (% reduction in paw volume 58.59%, 62.11% and 68.94% respectably) and membrane stabilizing action on human red blood cell membrane at concentration of 100, 250 and 500 mcg/ml showed 39.66%, 62.94% and 78.50% which are comparable with standard diclofenec.

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International Journal of Basic Medical Sciences and Pharmacy (IJBMSP): ISSN: 2049-4963