Synthesis, Chemical Characterization and Biological Evaluation of Zn (II), Fe (III) And Sb (III) Metal Complexes of 4-[(3-Bromophenyl)amino]-4-oxobutanoic acid

Kishwar Sultana, Najm ul Hassan Khan, Khadija Shahid


Present research report elucidates the synthesis, chemistry and biological evaluation of metal complexes of the ligand 4-[(3-Bromophenyl)amino]-4-oxobutanoic acid. The ligand was synthesized by reacting bromo Substituted aniline with succinic anhydride by fusion technique under solvent free condition. The compound was then reacted with Zn (II), Fe (III) and Sb (III) chlorides to form metal complexes. The structures of ligand and complexes were confirmed by physical data, spectral evaluation including FTIR, GCMS, 1H NMR, 13C NMR etc. The ligands and their complexes were screened for Carbonic anhydrase inhibition, alkaline phosphatase inhibition and antioxidant activity. Remarkable results were obtained for Zn and antimony complexes of the ligand.

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International Journal of Basic Medical Sciences and Pharmacy (IJBMSP): ISSN: 2049-4963