Prevalence, Types and Predictors of Potential Drug-Drug Interactions in an Internal Medicine Ward of The Mardan Medical Complex, Mardan,Kpk, Pakistan

Nizar Muhammad, Ruqayya Afridi


The aim of this study was to determine the prevalence, types and predictors of potential drug-drug interactions (pDDIs). In this retrospective study, medication records of 40 patients were randomly selected from the internal medicine ward and analyzed for pDDIs. A total of 30 interacting drug pairs resulted into 53 pDDIs. Overall 52.50% patients have at least 1 pDDI regardless of the type of severity; 12.50%, 25% and 42.50% patients have at least one major, moderate and minor pDDI. Out of 53 pDDI the basis of severity 58.49%, 26.41% and 15.41% were of minor, moderate and major types respectively; 96.30% were of delayed onset; whereas those with probable and suspected scientific evidences were 37.73% each. pDDIs were more prevalent in the internal medicine ward, majority of which were of minor type of severity. Patients prescribed with more than 7 number of medication were at high risk of occurrence of pDDIs.

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International Journal of Basic Medical Sciences and Pharmacy (IJBMSP): ISSN: 2049-4963